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When loose ends finally meet

Nature Structural & Molecular Biology volume 15, pages 12411242 (2008) | Download Citation

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The tumor suppressor protein 53BP1 decorates DNA damage sites and is instrumental for nonhomologous end joining. Evidence that 53BP1 facilitates synapsis of DNA ends by modulating chromatin dynamics reveals a hitherto unanticipated strategy for joining distant ends.

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Affiliations

  1. Michael S.Y. Huen and Junjie Chen are in the Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, Connecticut 06520, USA.  junjie.chen@yale.edu

    • Michael S Y Huen
    •  & Junjie Chen

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DOI

https://doi.org/10.1038/nsmb1208-1241

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