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The N-end rule at atomic resolution

Nature Structural & Molecular Biology volume 15, pages 12381240 (2008) | Download Citation

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The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. The N-end rule pathway, ubiquitin-dependent in eukaryotes, is also present in prokaryotes, which lack the ubiquitin system. An illuminating new study presents the crystal structure of a bacterial N-end rule recognition component in complex with a peptide containing a cognate degradation signal.

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Acknowledgements

I thank C. Brower, R. Deshaies, D. Finley, M. Hochstrasser, A. Shemorry and W. Tansey for comments. Studies in my laboratory are supported by grants from the US National Institutes of Health, the Ellison Medical Foundation and the Sandler Program for Asthma Research.

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Affiliations

  1. Alexander Varshavsky is in the Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.  avarsh@caltech.edu

    • Alexander Varshavsky

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DOI

https://doi.org/10.1038/nsmb1208-1238

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