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Is the spliceosome a ribonucleoprotein enzyme?

Nature Structural & Molecular Biology volume 15, pages 12351237 (2008) | Download Citation

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New work suggests that Prp8, a highly conserved protein in the heart of the spliceosome, both orients the substrate and participates in catalysis.

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References

  1. 1.

    & RNA 11, 533–557 (2005).

  2. 2.

    , , , & EMBO J. 27, 2929–2940 (2008).

  3. 3.

    et al. Nat. Struct. Mol. Biol. 15, 1199–1205 (2008).

  4. 4.

    , , , & Proc. Natl. Acad. Sci. USA 105, 13817–13822 (2008).

  5. 5.

    et al. Mol. Cell 9, 31–44 (2002).

  6. 6.

    et al. RNA 7, 1543–1553 (2001).

  7. 7.

    , , , & Mol. Cell 25, 615–624 (2007).

  8. 8.

    et al. Protein Sci. 16, 1024–1031 (2007).

  9. 9.

    , , , & RNA 12, 292–302 (2006).

  10. 10.

    , , , & RNA 5, 167–179 (1999).

  11. 11.

    & Genes Dev. 13, 1970–1982 (1999).

  12. 12.

    & Mol. Cell 14, 343–354 (2004).

  13. 13.

    & Genetics 143, 723–739 (1996).

  14. 14.

    & Genetics 155, 1667–1682 (2000).

  15. 15.

    et al. Mol. Cell 28, 264–276 (2007).

  16. 16.

    , , , & Nat. Struct. Mol. Biol. 11, 1237–1242 (2004).

  17. 17.

    , , & Nature 408, 881–884 (2000).

  18. 18.

    & Nat. Struct. Biol. 7, 850–854 (2000).

  19. 19.

    , & Mol. Cell 6, 317–328 (2000).

  20. 20.

    , & EMBO J. 14, 2602–2612 (1995).

  21. 21.

    & Mol. Cell 3, 55–64 (1999).

  22. 22.

    & Genetics 157, 1451–1467 (2001).

  23. 23.

    & RNA 1, 584–597 (1995).

Download references

Acknowledgements

Thanks to C. Maeder and C. Guthrie for discussions and help in preparing this News and Views.

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Affiliations

  1. John Abelson is in the Department of Biochemistry and Biophysics, the University of California San Francisco, San Francisco, California 94114.  johnabelson@gmail.com

    • John Abelson

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DOI

https://doi.org/10.1038/nsmb1208-1235

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