Last year Zhang, Kuriyan and colleagues demonstrated that an asymmetric dimer interaction between EGF receptor kinase domains is a key element of receptor activation. They now show that a cellular protein that inhibits receptor activity targets this dimer interface, not only uncovering an important regulatory mechanism but also opening a new route to therapeutic kinase inhibition.
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Leahy, D. A monkey wrench in the kinase machine. Nat Struct Mol Biol 14, 1120–1121 (2007). https://doi.org/10.1038/nsmb1207-1120
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DOI: https://doi.org/10.1038/nsmb1207-1120