Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

At the end, remodeling leads to eviction

The induction and repair of chromosome breaks is associated with myriad changes in chromatin. A recent study shows that chromatin remodeling that results in histone eviction at the break site requires the Mre11 complex and INO80 and that these events are important for efficient loading of the Rad51 recombinase.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Tsukuda, T., Fleming, A.B., Nickoloff, J.A. & Osley, M.A. Nature 438, 479–483 (2005).

    Article  Google Scholar 

  2. Redon, C. et al. Curr. Opin. Genet. Dev. 12, 162–169 (2002).

    Article  CAS  Google Scholar 

  3. Celeste, A. et al. Nat. Cell Biol. 5, 675–679 (2003).

    Article  CAS  Google Scholar 

  4. Paull, T.T. et al. Curr. Biol. 10, 886–895 (2000).

    Article  CAS  Google Scholar 

  5. Rogakou, E.P., Boon, C., Redon, C. & Bonner, W.M. J. Cell Biol. 146, 905–915 (1999).

    Article  CAS  Google Scholar 

  6. Shroff, R. et al. Curr. Biol. 14, 1703–1711 (2004).

    Article  CAS  Google Scholar 

  7. Huyen, Y. et al. Nature 432, 406–411 (2004).

    Article  CAS  Google Scholar 

  8. Shen, X., Mizuguchi, G., Hamiche, A. & Wu, C. Nature 406, 541–544 (2000).

    Article  CAS  Google Scholar 

  9. Bird, A.W. et al. Nature 419, 411–415 (2002).

    Article  CAS  Google Scholar 

  10. Downs, J.A. et al. Mol. Cell 16, 979–990 (2004).

    Article  CAS  Google Scholar 

  11. Morrison, A.J. et al. Cell 119, 767–775 (2004).

    Article  CAS  Google Scholar 

  12. Lee, S.E. et al. Cell 94, 399–409 (1998).

    Article  CAS  Google Scholar 

  13. Boeger, H. et al. FEBS Lett. 579, 899–903 (2005).

    Article  CAS  Google Scholar 

  14. Stracker, T.H., Theunissen, J.W., Morales, M. & Petrini, J.H. DNA Repair (Amst.) 3, 845–854 (2004).

    Article  CAS  Google Scholar 

  15. Usui, T., Ogawa, H. & Petrini, J.H. Mol. Cell 7, 1255–1266 (2001).

    Article  CAS  Google Scholar 

  16. D'Amours, D. & Jackson, S.P. Genes Dev. 15, 2238–2249 (2001).

    Article  CAS  Google Scholar 

  17. Grenon, M., Gilbert, C. & Lowndes, N.F. Nat. Cell Biol. 3, 844–847 (2001).

    Article  CAS  Google Scholar 

  18. Wiltzius, J.J., Hohl, M., Fleming, J.C. & Petrini, J.H. Nat. Struct. Mol. Biol. 12, 403–407 (2005).

    Article  CAS  Google Scholar 

  19. Krogh, B.O. & Symington, L.S. Annu. Rev. Genet. 38, 233–271 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petrini, J. At the end, remodeling leads to eviction. Nat Struct Mol Biol 12, 1028–1029 (2005). https://doi.org/10.1038/nsmb1205-1028

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb1205-1028

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing