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Coordinated control of splicing and translation

A new study reveals that extracellular signals can activate a signal-transduction cascade that simultaneously alters alternative splicing and translation of the same target. These concerted efforts probably serve to increase the speed and strength of the cellular response to changes in the extracellular environment.

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Figure 1: A model connecting signal transduction, alternative splicing and translation regulation.

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Graveley, B. Coordinated control of splicing and translation. Nat Struct Mol Biol 12, 1022–1023 (2005). https://doi.org/10.1038/nsmb1205-1022

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