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Coordinated control of splicing and translation

Nature Structural & Molecular Biology volume 12, pages 10221023 (2005) | Download Citation

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A new study reveals that extracellular signals can activate a signal-transduction cascade that simultaneously alters alternative splicing and translation of the same target. These concerted efforts probably serve to increase the speed and strength of the cellular response to changes in the extracellular environment.

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References

  1. 1.

    Trends Genet. 17, 100–107 (2001).

  2. 2.

    , & Nat. Rev. Mol. Cell Biol. 6, 386–398 (2005).

  3. 3.

    & Nat. Rev. Mol. Cell Biol. 5, 727–738 (2004).

  4. 4.

    et al. Nat. Struct. Mol. Biol. 12, 1037–1044 (2005).

  5. 5.

    RNA 6, 1197–1211 (2000).

  6. 6.

    , , & Mol. Cell 11, 837–843 (2003).

  7. 7.

    & Mol. Cell 7, 899–905 (2001).

  8. 8.

    et al. Genes Dev. 16, 594–607 (2002).

  9. 9.

    & Mol. Cell 16, 597–607 (2004).

  10. 10.

    & Cell 122, 365–378 (2005).

  11. 11.

    , , & Genes Dev. 18, 755–768 (2004).

  12. 12.

    & Trends Biochem. Sci. 30, 115–118 (2005).

  13. 13.

    et al. J. Biol. Chem. 280, 14302–14309 (2005).

  14. 14.

    , & Mol. Cell 9, 957–970 (2002).

  15. 15.

    & Nature 416, 499–506 (2002).

Download references

Author information

Affiliations

  1. The author is in the Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-3301, USA. graveley@neuron.uchc.edu

    • Brenton R Graveley

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DOI

https://doi.org/10.1038/nsmb1205-1022

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