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A bacterial big-MAC attack

Nature Structural & Molecular Biology volume 11, pages 11631164 (2004) | Download Citation

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Certain pathogens and bacterial toxins exhibit exquisite host specificity, the determinants of which often remain mysterious. A recent report shows that the human specificity of the pore-forming toxin intermedilysin (ILY), a member of the cholesterol-dependent cytolysins (CDCs), is due to its specific interaction with the human cluster of differentiation protein CD59.

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Affiliations

  1. Department of Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. gisou.vandergoot@medecine.unige.ch

    • Ioan Iacovache
    •  & F Gisou van der Goot

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DOI

https://doi.org/10.1038/nsmb1204-1163

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