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Hsp90: from structure to phenotype

A recent international conference focused on Hsp90, a molecular chaperone that plays a critical role in a diverse array of cellular processes including the assembly and maturation of some important 'client' proteins, many of which are involved in signal transduction.

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Figure 1: Cytosolic Hsp90 and its homologs Grp94, TRAP and HTPG along with numerous cochaperones form the cellular assembly machine.

Notes

  1. 1.

    *The EMBO workshop and second international conference on the Hsp90 Chaperone Machine was held in Gwatt, Switzerland, 25–29 September, 2004. For other information about the conference, see http://www.hsp90.org.

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Jackson, S., Queitsch, C. & Toft, D. Hsp90: from structure to phenotype. Nat Struct Mol Biol 11, 1152–1155 (2004). https://doi.org/10.1038/nsmb1204-1152

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