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Unleashing cell death: the Fas–FADD complex

Nature Structural & Molecular Biology volume 17, pages 12891290 (2010) | Download Citation

The interaction of the Fas death domain (DD) with the adaptor protein FADD is a critical step in assembling the death-inducing signaling complex (DISC). Using structural and biophysical approaches, two recent papers reveal the core stoichiometry to be a 5Fas:5FADD complex.

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Author information

Affiliations

  1. Sarah G. Hymowitz is in the Department of Structural Biology and Vishva M. Dixit is in the Department of Physiological Chemistry at Genentech, Inc., South San Francisco, California, USA.

    • Sarah G Hymowitz
    •  & Vishva M Dixit

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Competing interests

The authors are employees of Genentech, Inc.

Corresponding authors

Correspondence to Sarah G Hymowitz or Vishva M Dixit.

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DOI

https://doi.org/10.1038/nsmb1110-1289

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