The interaction of the Fas death domain (DD) with the adaptor protein FADD is a critical step in assembling the death-inducing signaling complex (DISC). Using structural and biophysical approaches, two recent papers reveal the core stoichiometry to be a 5Fas:5FADD complex.
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Katie Vicari
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Hymowitz, S., Dixit, V. Unleashing cell death: the Fas–FADD complex. Nat Struct Mol Biol 17, 1289–1290 (2010). https://doi.org/10.1038/nsmb1110-1289
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DOI: https://doi.org/10.1038/nsmb1110-1289
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