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An INKlination for epigenetic control of senescence

Nature Structural & Molecular Biology volume 15, pages 11331134 (2008) | Download Citation

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Much has been written and said about the links between the Ink4a-Arf locus, cellular senescence and stem-cell maintenance. Standing modestly in the shadows of these superstars of tumor suppression, the closely linked Ink4b gene is now emerging as a significant player in these events, and its regulation by a histone demethylase could provide new insights into how this remarkable locus is controlled.

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Affiliations

  1. Gordon Peters is at Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.  gordon.peters@cancer.org.uk

    • Gordon Peters

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DOI

https://doi.org/10.1038/nsmb1108-1133

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