Much has been written and said about the links between the Ink4a-Arf locus, cellular senescence and stem-cell maintenance. Standing modestly in the shadows of these superstars of tumor suppression, the closely linked Ink4b gene is now emerging as a significant player in these events, and its regulation by a histone demethylase could provide new insights into how this remarkable locus is controlled.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
Epigenetics & Chromatin Open Access 02 December 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kouzarides, T. Cell 128, 693–705 (2007).
Boyer, L.A. et al. Nature 441, 349–353 (2006).
Bracken, A.P., Dietrich, N., Pasini, D., Hansen, K.H. & Helin, K. Genes Dev. 20, 1123–1136 (2006).
Bracken, A.P. et al. Genes Dev. 21, 525–530 (2007).
Kia, S.K., Gorski, M.M., Giannakopoulos, S. & Verrijzer, C.P. Mol. Cell. Biol. 28, 3457–3464 (2008).
Valk-Lingbeek, M.E., Bruggeman, S.W. & van Lohuizen, M. Cell 118, 409–18 (2004).
Jacobs, J.J., Kieboom, K., Marino, S., DePinho, R.A. & van Lohuizen, M. Nature 397, 164–168 (1999).
He, J., Kallin, E.M., Tsukada, Y. & Zhang, Y. Nat. Struct. Mol. Biol. 15, 1169–1175 (2008).
Pfau, R. et al. Proc. Natl. Acad. Sci. USA 105, 1907–1912 (2008).
Serrano, M. et al. Cell 85, 27–37 (1996).
Kamijo, T. et al. Cell 91, 649–659 (1997).
Latres, E. et al. EMBO J. 19, 3496–3506 (2000).
Krimpenfort, P., Quon, K.C., Mooi, W.J., Loonstra, A. & Berns, A. Nature 413, 83–86 (2001).
Sharpless, N.E. et al. Nature 413, 86–91 (2001).
Sharpless, N.E., Ramsey, M.R., Balasubramanian, P., Castrillon, D.H. & DePinho, R.A. Oncogene 23, 379–385 (2004).
Krimpenfort, P. et al. Nature 448, 943–946 (2007).
Bruggeman, S.W. et al. Genes Dev. 19, 1438–1443 (2005).
Molofsky, A.V., He, S., Bydon, M., Morrison, S.J. & Pardal, R. Genes Dev. 19, 1432–1437 (2005).
Suzuki, T., Minehata, K., Akagi, K., Jenkins, N.A. & Copeland, N.G. EMBO J. 25, 3422–3431 (2006).
Sanchez, C. et al. Mol. Cell. Proteomics 6, 820–834 (2007).
Gearhart, M.D., Corcoran, C.M., Wamstad, J.A. & Bardwell, V.J. Mol. Cell. Biol. 26, 6880–6889 (2006).
Kim, S.H. et al. J. Cell Sci. 119, 2435–2443 (2006).
Lagarou, A. et al. Genes Dev. 22, 2799–2810 (2008).
Herman, J.G. et al. Cancer Res. 57, 837–841 (1997).
Quesnel, B. et al. Blood 91, 2985–2990 (1998).
Collado, M. & Serrano, M. Nat. Rev. Cancer 6, 472–476 (2006).
Hannon, G.J. & Beach, D. Nature 371, 257–261 (1994).
Seoane, J. et al. Nat. Cell Biol. 3, 400–408 (2001).
Staller, P. et al. Nat. Cell Biol. 3, 392–399 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peters, G. An INKlination for epigenetic control of senescence. Nat Struct Mol Biol 15, 1133–1134 (2008). https://doi.org/10.1038/nsmb1108-1133
Issue Date:
DOI: https://doi.org/10.1038/nsmb1108-1133
This article is cited by
-
Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals
Cell Research (2015)
-
Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells
Oncogene (2013)
-
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
Epigenetics & Chromatin (2009)
