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Integration of an electric-metal sensory experience in the Slo1 BK channel

Nature Structural & Molecular Biology volume 15, pages 1130–1132 (2008)Cite this article

A Corrigendum to this article was published on 01 May 2009

This article has been updated

The open gate of the BK-type K+ channel is stabilized when the voltage-sensor domains (VSDs) are activated by depolarization and the intracellular Mg2+ sensors are occupied. A systematic investigation reveals that each Mg2+ is bound by the transmembrane VSD and cytoplasmic ligand-sensing domain from two adjacent subunits, suggesting that relative positions of sensor and gate domains of BK channels may differ substantially from those suggested by homology models.

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Figure 1: Gate, voltage-sensor and Mg2+-sensor modules in BK channels.
Figure 2: BK channel homology models, from an extracellular perspective.

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  • 06 May 2009

    In the version of this article initially published, the incorrect PDB code for the MthK open channel structure was provided in the legend to Figure 1. The correct PDB code for this structure is 1LNQ. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Frank T. Horrigan is in the Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, MS:BCM335, Houston, Texas 77030, USA. horrigan@bcm.tmc.edu,

    Frank T Horrigan

  2. Toshinori Hoshi is in the Department of Physiology, 3700 Hamilton Walk, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. hoshi@hoshi.org,

    Toshinori Hoshi

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  1. Frank T Horrigan
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Horrigan, F., Hoshi, T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol 15, 1130–1132 (2008). https://doi.org/10.1038/nsmb1108-1130

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