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Sensing of DNA damage by XPC/Rad4: one protein for many lesions

Nature Structural & Molecular Biology volume 14, pages 887–888 (2007)Cite this article

Through its crucial role in DNA damage recognition and initiation of nucleotide excision repair in mammals, XPC protein represents a first line of defense against carcinogenesis. The recent elucidation of the molecular structure of the yeast XPC homolog Rad4 provides new insights into how eukaryotic cells recognize structurally diverse DNA lesions.

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Figure 1: Model for DNA damage recognition by XPC or its homolog Rad4.

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Authors and Affiliations

  1. Kaoru Sugasawa is at the Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Nada-ku, Kobe 657-8501, Japan. ksugasawa@garnet.kobe-u.ac.jp,

    Kaoru Sugasawa

  2. Fumio Hanaoka is at the Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan. fhanaoka@fbs.osaka-u.ac.jp,

    Fumio Hanaoka

Authors
  1. Kaoru Sugasawa
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  2. Fumio Hanaoka
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Sugasawa, K., Hanaoka, F. Sensing of DNA damage by XPC/Rad4: one protein for many lesions. Nat Struct Mol Biol 14, 887–888 (2007). https://doi.org/10.1038/nsmb1007-887

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