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Transmembrane signaling by asymmetry

Nature Structural & Molecular Biology volume 13, pages 861–862 (2006)Cite this article

The structure of the ligand-binding domains of Vibrio harveyi LuxPQ bound to Autoinducer-2 reveals a dramatic asymmetry in quaternary structure induced by ligand binding. Structures of receptor-sensing domains in both occupied and unoccupied states provide a foundation for postulating mechanisms of transmembrane signaling.

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Figure 1: Schematic representation of quaternary structure asymmetry induced by AI-2 binding to the sensor histidine kinase LuxPQ.

Katie Ris

References

  1. Neiditch, M.B. et al. Cell 126, 1095–1108 (2006).

    Article  CAS  Google Scholar 

  2. Camilli, A. & Bassler, B.L. Science 311, 1113–1116 (2006).

    Article  CAS  Google Scholar 

  3. Keller, L. & Surette, M.G. Nat. Rev. Microbiol. 4, 249–258 (2006).

    Article  CAS  Google Scholar 

  4. Chen, X. et al. Nature 415, 545–549 (2002).

    Article  CAS  Google Scholar 

  5. Quiocho, F.A. & Ledvina, P.S. Mol. Microbiol. 20, 17–25 (1996).

    Article  CAS  Google Scholar 

  6. Galperin, M.Y. BMC Microbiol. 5, 35 (2005).

    Article  Google Scholar 

  7. Yonekura, K. et al. Science 290, 2148–2152 (2000).

    Article  CAS  Google Scholar 

  8. Milburn, M.V. et al. Science 254, 1342–1347 (1991).

    Article  CAS  Google Scholar 

  9. Cho, U.S. et al. J. Mol. Biol. 356, 1193–1206 (2006).

    Article  CAS  Google Scholar 

  10. Neiditch, M.B., Federle, M.J., Miller, S.T., Bassler, B.L. & Hughson, F.M. Mol. Cell 18, 507–518 (2005).

    Article  CAS  Google Scholar 

  11. Marina, A., Waldburger, C.D. & Hendrickson, W.A. EMBO J. 24, 4247–4259 (2005).

    Article  CAS  Google Scholar 

  12. Pan, S.Q., Charles, T., Jin, S., Wu, Z.-L. & Nester, E.W. Proc. Natl. Acad. Sci. USA 90, 9939–9943 (1993).

    Article  CAS  Google Scholar 

  13. Ninfa, E.G., Atkinson, M.R., Kamberov, E.S. & Ninfa, A.J. J. Bacteriol. 175, 7024–7032 (1993).

    Article  CAS  Google Scholar 

  14. Wolfe, A.J. & Stewart, R.C. Proc. Natl. Acad. Sci. USA 90, 1518–1522 (1993).

    Article  CAS  Google Scholar 

  15. Falke, J.J. & Hazelbauer, G.L. Trends Biochem. Sci. 26, 257–265 (2001).

    Article  CAS  Google Scholar 

  16. Vaknin, A. & Berg, H.C. Proc. Natl. Acad. Sci. USA 103, 592–596 (2006).

    Article  CAS  Google Scholar 

  17. Zhang, Y. et al. Proc. Natl. Acad. Sci. USA 96, 939–944 (1999).

    Article  CAS  Google Scholar 

  18. Li, X. & Roseman, S. Proc. Natl. Acad. Sci. USA 101, 627–631 (2004).

    Article  CAS  Google Scholar 

  19. Biemann, H.-P. & Koshland, D.E. Jr. Biochemistry 33, 629–634 (1994).

    Article  CAS  Google Scholar 

  20. Enemark, E.J. & Joshua-Tor, L. Nature 442, 270–275 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Biochemistry, Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, and the Howard Hughes Medical Institute, Piscataway, 08854, New Jersey, USA

    Ann M Stock

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Stock, A. Transmembrane signaling by asymmetry. Nat Struct Mol Biol 13, 861–862 (2006). https://doi.org/10.1038/nsmb1006-862

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