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CUT it out: silencing of noise in the transcriptome

Nature Structural & Molecular Biology volume 13, pages 860861 (2006) | Download Citation

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Eukaryotic transcriptomes are considerably larger than estimated from simple gene counts. However, much of this 'excess' RNA is immediately cleared from cells. Two recent studies reveal that so-called cryptic unstable transcripts constitutively transcribed from the yeast genome are rapidly eliminated in a process that couples transcription termination to RNA degradation.

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Affiliations

  1. Søren Lykke-Andersen and Torben Heick Jensen are at the Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark. thj@mb.au.dk

    • Søren Lykke-Andersen
    •  & Torben Heick Jensen

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DOI

https://doi.org/10.1038/nsmb1006-860

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