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mRNA processing and genomic instability

A new study adds to our understanding of the interconnection between different nuclear processes by showing that a 'classical' metazoan precursor mRNA–processing factor functions to prevent transcription-associated genomic instability.

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Figure 1: Simplified view of cotranscriptional formation of R loops, as could occur in ASF/SF2–depleted cells.

References

  1. Hirose, Y. & Manley, J.L. Genes Dev. 14, 1415–1429 (2000).

    CAS  Google Scholar 

  2. Maniatis, T. & Reed, R. Nature 416, 499–506 (2002).

    Article  CAS  Google Scholar 

  3. Proudfoot, N.J., Furger, A. & Dye, M.J. Cell 108, 501–512 (2002).

    Article  CAS  Google Scholar 

  4. Buratowski, S. Curr. Opin. Cell Biol. 17, 257–261 (2005).

    Article  CAS  Google Scholar 

  5. Ge, H. & Manley, J.L. Cell 62, 25–34 (1990).

    Article  CAS  Google Scholar 

  6. Krainer, A.R., Conway, G.C. & Kozak, D. Cell 62, 35–42 (1990).

    Article  CAS  Google Scholar 

  7. Li, X. & Manley, J.L. Cell 122, 365–378 (2005).

    Article  CAS  Google Scholar 

  8. Yu, K., Chedin, F., Hsieh, C.-L., Wilson, T.E. & Lieber, M. Nat. Immunol. 4, 442–451 (2003).

    Article  CAS  Google Scholar 

  9. Huertas, P. & Aguilera, A. Mol. Cell 12, 711–721 (2003).

    Article  CAS  Google Scholar 

  10. Li, Y., Wang, X., Zhang, X. & Goodrich, D.W. Mol. Cell. Biol. 25, 4023–4033 (2005).

    Article  CAS  Google Scholar 

  11. Masuda, S. et al. Genes Dev. 19, 1512–1517 (2005).

    Article  CAS  Google Scholar 

  12. Daneholt, B. Chromosoma 110, 173–185 (2001).

    Article  CAS  Google Scholar 

  13. Lai, M.-C. & Tarn, W.-Y. J. Biol. Chem. 279, 31745–31749 (2004).

    Article  CAS  Google Scholar 

  14. Aguilera, A. Curr. Opin. Cell Biol. 17, 242–250 (2005).

    Article  CAS  Google Scholar 

  15. Reed, R. & Cheng, H. Curr. Opin. Cell Biol. 17, 269–273 (2005).

    Article  CAS  Google Scholar 

  16. Blanchette, M., Labourier, E., Green, R.E., Brenner, S.E. & Río, D.C. Mol. Cell 14, 775–786 (2004).

    Article  CAS  Google Scholar 

  17. Luna, R., Jimeno, S., Marí n, M., Huertas, P. & Aguilera, A. Mol. Cell 18, 711–722 (2005).

    Article  CAS  Google Scholar 

  18. Hurt, E., Luo, M.J., Rother, S., Reed, R. & Strässer, K. Proc. Natl. Acad. Sci. USA 101, 1858–1862 (2004).

    Article  CAS  Google Scholar 

  19. Drolet, M. et al. Proc. Natl. Acad. Sci. USA 92, 3526–3530 (1995).

    Article  CAS  Google Scholar 

  20. Massé, E., Phoenix, P. & Drolet, M. J. Biol. Chem. 272, 12816–12823 (1997).

    Article  Google Scholar 

  21. Yu, K., Roy, D., Bayramyan, M., Haworth, I.S. & Lieber, M.R. Mol. Cell. Biol. 25, 1730–1736 (2005).

    Article  CAS  Google Scholar 

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Aguilera, A. mRNA processing and genomic instability. Nat Struct Mol Biol 12, 737–738 (2005). https://doi.org/10.1038/nsmb0905-737

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