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Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion

Nature Structural & Molecular Biology volume 17, pages 928–930 (2010)Cite this article

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The HIV-1 Tat protein promotes viral transcription elongation by recruiting P-TEFb to RNA element TAR on the viral mRNA. Recent work from D'Orso and Frankel uncovers unexpected aspects of this process.

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Figure 1: Revised model of HIV-1 Tat transactivation.
Figure 2: Alternative pools of P-TEFb for HIV-1 Tat transactivation.

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Authors and Affiliations

  1. Matjaz Barboric and Tina Lenasi are in the Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.,

    Matjaz Barboric & Tina Lenasi

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  1. Matjaz Barboric
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  2. Tina Lenasi
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Correspondence to Matjaz Barboric.

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Barboric, M., Lenasi, T. Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion. Nat Struct Mol Biol 17, 928–930 (2010). https://doi.org/10.1038/nsmb0810-928

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