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Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion

The HIV-1 Tat protein promotes viral transcription elongation by recruiting P-TEFb to RNA element TAR on the viral mRNA. Recent work from D'Orso and Frankel uncovers unexpected aspects of this process.

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Figure 1: Revised model of HIV-1 Tat transactivation.
Figure 2: Alternative pools of P-TEFb for HIV-1 Tat transactivation.

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Correspondence to Matjaz Barboric.

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Barboric, M., Lenasi, T. Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion. Nat Struct Mol Biol 17, 928–930 (2010). https://doi.org/10.1038/nsmb0810-928

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  • DOI: https://doi.org/10.1038/nsmb0810-928

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