To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.
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Acknowledgements
We thank J.M. Kim and Y. Kee for helpful discussions and critical reading of the manuscript. A.D.D. is supported by US National Institutes of Health grant NIH-RO1-DK43889.
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Huang, M., D'Andrea, A. A new nuclease member of the FAN club. Nat Struct Mol Biol 17, 926–928 (2010). https://doi.org/10.1038/nsmb0810-926
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DOI: https://doi.org/10.1038/nsmb0810-926
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