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Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'

Nature Structural & Molecular Biology volume 15, pages 775–776 (2008)Cite this article

Transcriptional termination by RNA polymerase II in yeast occurs by two different pathways: stable or cryptic unstable transcripts use the Nrd1 complex, whereas mRNA uses 3′ cleavage and polyadenylation factors together with Rat1 exonuclease. How RNA polymerase II selects which pathway to use is discussed.

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Figure 1: Three modes of Pol II termination in yeast.

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Authors and Affiliations

  1. Ana G. Rondon, Hannah E. Mischo and Nick J. Proudfoot are at the Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK. nicholas.proudfoot@path.ox.ac.uk,

    Ana G Rondon, Hannah E Mischo & Nick J Proudfoot

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  1. Ana G Rondon
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  2. Hannah E Mischo
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  3. Nick J Proudfoot
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Rondon, A., Mischo, H. & Proudfoot, N. Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'. Nat Struct Mol Biol 15, 775–776 (2008). https://doi.org/10.1038/nsmb0808-775

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