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Finding the right spot to start transcription

Nature Structural & Molecular Biology volume 14, pages 686–687 (2007)Cite this article

How does RNA polymerase II cooperate with initiation factors to locate transcription start sites throughout the genome? A new cross-linking approach reveals previously unknown initiation factor–binding sites on the polymerase surface. The resulting model of the transcription initiation complex suggests that initiation factors cooperate above and inside the polymerase active center cleft to open DNA and find the transcription start site.

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Figure 1: Topological model of the transcription preinitiation complex according to Chen et al.6.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Patrick Cramer is at the Gene Center Munich and the Center for Integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. cramer@lmb.uni-muenchen.de,

    Patrick Cramer

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Cramer, P. Finding the right spot to start transcription. Nat Struct Mol Biol 14, 686–687 (2007). https://doi.org/10.1038/nsmb0807-686

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