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Blocking HIV-1 virus assembly

Nature Structural & Molecular Biology volume 12, pages 638639 (2005) | Download Citation

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Two recent papers identify the first peptide inhibitor that binds to the structural protein of HIV-1, thereby blocking assembly of both immature and mature virus-like particles in vitro. These studies open the door to a strategy for the development of new therapies against the virus.

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References

  1. 1.

    , , , & Science 283, 80–83 (1999).

  2. 2.

    et al. EMBO J. 19, 103–113 (2000).

  3. 3.

    , , & Nature 407, 409–413 (2000).

  4. 4.

    et al. J. Mol. Biol. 325, 759–772 (2003).

  5. 5.

    et al. Nat. Struct. Mol. Biol. 12, 671–677 (2005).

  6. 6.

    , , , & EMBO J. 22, 1707–1715 (2003).

  7. 7.

    & J. Virol. 75, 242–250 (2001).

  8. 8.

    , , , & Mol. Cell 17, 137–143 (2005).

  9. 9.

    , , , & Nat. Struct. Mol. Biol. 12, 678–682 (2005).

  10. 10.

    et al. Proc. Natl. Acad. Sci. USA 100, 13555–13560 (2003).

  11. 11.

    et al. J. Virol. 78, 922–929 (2004).

  12. 12.

    et al. J. Mol. Biol. 327, 1013–1020 (2003).

  13. 13.

    et al. Nat. Struct. Mol. Biol. 11, 672–675 (2004).

Download references

Author information

Affiliations

  1. The author is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. vmv1@cornell.edu

    • Volker M Vogt

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DOI

https://doi.org/10.1038/nsmb0805-638

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