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Toward a unified theory for repeat expansions

Nature Structural & Molecular Biology volume 12, pages 635637 (2005) | Download Citation

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Two studies now explain why triplet DNA repeats tend to expand in the human genome, causing such severe hereditary neurological disorders as myotonic dystrophy and Huntington disease.

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Acknowledgements

I thank K. Mirkin for her constructive criticism. U.S. National Institute of General Medical Sciences grant GM 60987 supported my studies.

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Affiliations

  1. The author is in the Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607. mirkin@uic.edu

    • Sergei M Mirkin

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https://doi.org/10.1038/nsmb0805-635

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