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Reversing DNA damage with a directional bias

Nature Structural & Molecular Biology volume 11, pages 688–690 (2004)Cite this article

Structures of the human O6-alkylguanine-DNA alkyltransferase bound to substrate together with biochemical analysis provide clues to substrate acquisition and recognition, as well as details of the methyl transfer reaction catalyzed by this direct DNA repair protein.

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Figure 1: Specific reference points for AGT's interaction with substrate after flipping.
Figure 2: Putative template scanning and cleansing mechanism for AGT.

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Acknowledgements

Preparation of this News and Views was supported by NIH grants RO1-CA-55042 and 5PO1-CA92584. L.D.S. is an Ellison American Cancer Society Research Professor and T.J.B. is a Merck-MIT Computational and Systems Biology Fellow.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany-SUNY, Rensselaer, 12144, New York, USA

    Thomas J Begley

  2. Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, Massachusetts

    Leona D Samson

Authors
  1. Thomas J Begley
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  2. Leona D Samson
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Begley, T., Samson, L. Reversing DNA damage with a directional bias. Nat Struct Mol Biol 11, 688–690 (2004). https://doi.org/10.1038/nsmb0804-688

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