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Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation

Nature Structural & Molecular Biology volume 14, pages 572573 (2007) | Download Citation

MicroRNAs are small, noncoding RNAs that regulate gene expression in eukaryotes. The multipurpose protein hnRNP A1, a well-known factor in the regulation of precursor messenger RNA splicing, has now been implicated in the biogenesis of the microRNA miR-18a, shedding further light on the emerging topic of post-transcriptional regulation of microRNA expression.

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Acknowledgements

We thank K. Heindl and S. Weitzer for critically reading the manuscript.

Author information

Affiliations

  1. Anne Færch Nielsen is in the Department of Molecular Biology, University of Aarhus, CF Møllers Allé 1130, 8000 Aarhus C, Denmark

    • Anne Færch Nielsen
  2. Philipp J. F. Leuschner and Javier Martinez are at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, 1030, Vienna, Austria.  javier.martinez@imba.oeaw.ac.at

    • Philipp J F Leuschner
    •  & Javier Martinez

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Competing interests

The authors declare no competing financial interests.

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DOI

https://doi.org/10.1038/nsmb0707-572

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