SecA is an essential eubacterial protein in which the ATPase motor from DEAD-box RNA helicases has adapted to function as a processive polypeptide pump. A new report suggests that a disorder-order transition in the DEAD-box motor is responsible for distinctive thermodynamic features of SecA's conformationally coupled ATPase cycle.
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Cavanaugh, L., Palmer, A., Gierasch, L. et al. Disorder breathes life into a DEAD motor. Nat Struct Mol Biol 13, 566–569 (2006). https://doi.org/10.1038/nsmb0706-566
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DOI: https://doi.org/10.1038/nsmb0706-566
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