Removal of the poly(A) tail is the initial step in targeting an mRNA for degradation in budding yeast as well as in metazoans. But in fission yeast a new study reveals an additional pathway that adds uridines to the poly(A) tail of mRNA to initiate the degradation pathway.
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Marzluff, W. A new way to initiate mRNA degradation. Nat Struct Mol Biol 16, 613–614 (2009). https://doi.org/10.1038/nsmb0609-613
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DOI: https://doi.org/10.1038/nsmb0609-613
