Cooperation between the DNA recombinase RAD51 and the breast cancer susceptibility protein BRCA2 is crucial for the repair of double-strand DNA breaks. Two papers provide new insight into the BRCA2-RAD51 interaction, revealing two different sets of motifs within BRCA2 that bind structurally distinct forms of RAD51. The balance between these interactions seems to be crucial for the function of BRCA2 in DNA repair.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
Strahlentherapie und Onkologie Open Access 07 July 2023
-
Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology
Cancer Immunology, Immunotherapy Open Access 13 May 2023
-
Homologous recombination proficiency in ovarian and breast cancer patients
BMC Cancer Open Access 28 October 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wooster, R. & Weber, B.L. N. Engl. J. Med. 348, 2339–2347 (2003).
Gudmundsdottir, K. & Ashworth, A. Oncogene 25, 5864–5874 (2006).
Hoeijmakers, J.H. Nature 411, 366–374 (2001).
Yu, D.S. et al. Mol. Cell 12, 1029–1041 (2003).
Esashi, F., Galkin, V., Yu, X., Egelman, E.H. & West, S. Nat. Struct. Mol. Biol. 14, 468–474 (2007).
Davies, O.R. & Pellegrini, L. Nat. Struct. Mol. Biol. 14, 475–483 (2007).
Esashi, F. et al. Nature 434, 598–604 (2005).
Petalcorin, M.I., Galkin, V.E., Yu, X., Egelman, E.H. & Boulton, S.J. Proc. Natl. Acad. Sci. USA 104, 8299–8304 (2007).
Gayther, S.A. et al. Nat. Genet. 15, 103–105 (1997).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Lord, C., Ashworth, A. RAD51, BRCA2 and DNA repair: a partial resolution. Nat Struct Mol Biol 14, 461–462 (2007). https://doi.org/10.1038/nsmb0607-461
Issue Date:
DOI: https://doi.org/10.1038/nsmb0607-461
This article is cited by
-
Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology
Cancer Immunology, Immunotherapy (2023)
-
Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
Strahlentherapie und Onkologie (2023)
-
Significant association of BRCA1 (rs1799950), BRCA2 (rs144848) and TP53 (rs1042522) polymorphism with breast cancer risk in Pashtun population of Khyber Pakhtunkhwa, Pakistan
Molecular Biology Reports (2023)
-
Homologous recombination proficiency in ovarian and breast cancer patients
BMC Cancer (2021)
-
MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells
Oncogene (2019)