Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hsp90 structure: when two ends meet

Nature Structural & Molecular Biology volume 13, pages 478–480 (2006)Cite this article

The crystal structure of the full-length yeast Hsp90 sheds new light on the conformational cycle and the functional regulation of this important molecular chaperone.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Working model of the conformational cycle of Hsp90.
Figure 2: Crystal structure of Hsp90 in complex with p23 (ref. 2).

References

  1. Young, J.C., Moarefi, I. & Hartl, F.U. J. Cell Biol. 154, 267–273 (2001).

    Article  CAS  Google Scholar 

  2. Ali, M.M.U. et al. Nature 440, 1013–1017 (2006).

    Article  CAS  Google Scholar 

  3. Scheufler, C. et al. Cell 101, 199–210 (2000).

    Article  CAS  Google Scholar 

  4. Whitesell, L. & Lindquist, S.L. Nat. Rev. Cancer 5, 761–772 (2005).

    Article  CAS  Google Scholar 

  5. Dutta, R. & Inouye, M. Trends Biochem. Sci. 25, 24–28 (2000).

    Article  CAS  Google Scholar 

  6. Huai, Q. et al. Structure 13, 579–590 (2005).

    Article  CAS  Google Scholar 

  7. Harris, S.F., Shiau, A.K. & Agard, D.A. Structure 12, 1087–1097 (2004).

    Article  CAS  Google Scholar 

  8. Richter, K., Walter, S. & Buchner, J. J. Mol. Biol. 342, 1403–1413 (2004).

    Article  CAS  Google Scholar 

  9. Richter, K., Reinstein, J. & Buchner, J. J. Biol. Chem. 277, 44905–44910 (2002).

    Article  CAS  Google Scholar 

  10. Meyer, P. et al. Mol. Cell 11, 647–658 (2003).

    Article  CAS  Google Scholar 

  11. Meyer, P. et al. EMBO J. 23, 511–519 (2004).

    Article  CAS  Google Scholar 

  12. Harst, A., Lin, H. & Obermann, W.M. Biochem. J. 387, 789–796 (2005).

    Article  CAS  Google Scholar 

  13. Johnson, J.L. & Toft, D.O. J. Biol. Chem. 269, 24989–24993 (1994).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152, Germany

    Andreas Bracher & F Ulrich Hartl

Authors
  1. Andreas Bracher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F Ulrich Hartl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bracher, A., Hartl, F. Hsp90 structure: when two ends meet. Nat Struct Mol Biol 13, 478–480 (2006). https://doi.org/10.1038/nsmb0606-478

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0606-478

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing