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The human Pol III transcriptome and gene information flow

In this issue, three papers report the distribution of the RNA polymerase III (Pol III) machinery, including transcription factor IIIB, transcription factor IIIC and Pol III itself, across the human genome. These studies reveal cell type–specific expression of Pol III genes, functional interplay between the Pol II and Pol III transcriptional machineries and the potential involvement of Pol III genes in chromosome organization.

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Figure 1: Schematic representation of three typical loci exemplifying cross-regulation of Pol III and Pol II transcription.


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Correspondence to Ken-ichi Noma or Rohinton T Kamakaka.

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Noma, Ki., Kamakaka, R. The human Pol III transcriptome and gene information flow. Nat Struct Mol Biol 17, 539–541 (2010).

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