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Budding insights on cell polarity

The yeast proteins Sro7 and Sro77, and their metazoan relatives Lgl and tomosyn, interact with plasma membrane SNARE proteins and control cell polarity. Recently, the crystal structure of yeast Sro7 has been solved, yielding fascinating insights and even more unanswered questions concerning the molecular mechanism of these proteins.

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Figure 1: Schematic overview of the Sro7 and the tomosyn SNARE complex structures.


  1. Novick, P. et al. Biochem. Soc. Trans. 34, 683–686 (2006).

    Article  CAS  Google Scholar 

  2. Munson, M. & Novick, P. Nat. Struct. Mol. Biol. 13, 577–581 (2006).

    Article  CAS  Google Scholar 

  3. Zhang, X. et al. J. Cell Biol. 170, 273–283 (2005).

    Article  CAS  Google Scholar 

  4. Lehman, K., Rossi, G., Adamo, J.E. & Brennwald, P. J. Cell Biol. 146, 125–140 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Hattendorf, D.A., Andreeva, A., Gangar, A., Brennwald, P.J. & Weis, W.I. Nature 446, 567–571 (2007).

    Article  CAS  Google Scholar 

  6. Hong, W. Biochim. Biophys. Acta 1744, 493–517 (2005).

    PubMed  Google Scholar 

  7. Jahn, R. & Scheller, R.H. Nat. Rev. Mol. Cell Biol. 7, 631–643 (2006).

    Article  CAS  Google Scholar 

  8. Humbert, P.O., Dow, L.E. & Russell, S.M. Trends Cell Biol. 16, 622–630 (2006).

    Article  CAS  Google Scholar 

  9. Wirtz-Peitz, F. & Knoblich, J.A. Trends Cell Biol. 16, 234–241 (2006).

    Article  CAS  Google Scholar 

  10. Larsson, K. et al. J. Biol. Chem. 273, 33610–33618 (1998).

    Article  CAS  Google Scholar 

  11. Fujita, Y. et al. Neuron 20, 905–915 (1998).

    Article  CAS  Google Scholar 

  12. Musch, A. et al. Mol. Biol. Cell 13, 158–168 (2002).

    Article  CAS  Google Scholar 

  13. Voegtli, W.C., Madrona, A.Y. & Wilson, D.K. J. Biol. Chem. 278, 34373–34379 (2003).

    Article  CAS  Google Scholar 

  14. Mohri, K., Vorobiev, S., Fedorov, A.A., Almo, S.C. & Ono, S. J. Biol. Chem. 279, 31697–31707 (2004).

    Article  CAS  Google Scholar 

  15. Appleton, B.A., Wu, P. & Wiesmann, C. Structure 14, 87–96 (2006).

    Article  CAS  Google Scholar 

  16. Napetschnig, J., Blobel, G. & Hoelz, A. Proc. Natl. Acad. Sci. USA 104, 1783–1788 (2007).

    Article  CAS  Google Scholar 

  17. Brennwald, P. et al. Cell 79, 245–258 (1994).

    Article  CAS  Google Scholar 

  18. Pobbati, A.V., Razeto, A., Boddener, M., Becker, S. & Fasshauer, D. J. Biol. Chem. 279, 47192–47200 (2004).

    Article  CAS  Google Scholar 

  19. Masuda, E.S., Huang, B.C., Fisher, J.M., Luo, Y. & Scheller, R.H. Neuron 21, 479–480 (1998).

    Article  CAS  Google Scholar 

  20. Fasshauer, D., Sutton, R.B., Brünger, A.T. & Jahn, R. Proc. Natl. Acad. Sci. USA 95, 15781–15786 (1998).

    Article  CAS  Google Scholar 

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Fasshauer, D., Jahn, R. Budding insights on cell polarity. Nat Struct Mol Biol 14, 360–362 (2007).

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