Proper establishment, maintenance and removal of covalent post-translational modifications on histones are essential for normal cell physiology. In this issue, Nicolas et al. describe the characterization of two physically and functionally distinct Clr6 (Rpd3)-containing histone deacetylase complexes in fission yeast and implicate their activity in a number of processes, including transcriptional regulation, silencing and genomic integrity.
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Acknowledgements
We thank C.J. Ingles and G. Cagney for critically reading the manuscript, M. Shales for help with artwork and R. Rothstein and D. Alvaro for sharing unpublished results.
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Roguev, A., Krogan, N. SIN-fully silent: HDAC complexes in fission yeast. Nat Struct Mol Biol 14, 358–359 (2007). https://doi.org/10.1038/nsmb0507-358
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DOI: https://doi.org/10.1038/nsmb0507-358
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