SIN-fully silent: HDAC complexes in fission yeast

Article metrics

Proper establishment, maintenance and removal of covalent post-translational modifications on histones are essential for normal cell physiology. In this issue, Nicolas et al. describe the characterization of two physically and functionally distinct Clr6 (Rpd3)-containing histone deacetylase complexes in fission yeast and implicate their activity in a number of processes, including transcriptional regulation, silencing and genomic integrity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Comparison between Rpd3 (Clr6) complexes in S. cerevisiae and S. pombe.

References

  1. 1

    Henry, K.W. et al. Genes Dev. 17, 2648–2663 (2003).

  2. 2

    Nussenzweig, A. & Paull, T. Nature 439, 406–407 (2006).

  3. 3

    Shahbazian, M.D. & Grunstein, M. Annu. Rev. Biochem., published online 15 March 2007.

  4. 4

    Klose, R.J. & Zhang, Y. Nat. Rev. Mol. Cell Biol. 8, 307–318 (2007).

  5. 5

    Taunton, J., Hassig, C.A. & Schreiber, S.L. Science 272, 408–411 (1996).

  6. 6

    Nicolas, E. et al. Nat. Struct. Mol. Biol. 14, 372–380 (2007).

  7. 7

    Jazayeri, A., McAinsh, A.D. & Jackson, S.P. Proc. Natl. Acad. Sci. USA 101, 1644–1649 (2004).

  8. 8

    Tamburini, B.A. & Tyler, J.K. Mol. Cell. Biol. 25, 4903–4913 (2005).

  9. 9

    Vogelauer, M., Rubbi, L., Lucas, I., Brewer, B.J. & Grunstein, M. Mol. Cell 10, 1223–1233 (2002).

  10. 10

    Carrozza, M.J. et al. Cell 123, 581–592 (2005).

  11. 11

    Keogh, M.C. et al. Cell 123, 593–605 (2005).

  12. 12

    Loewith, R. et al. J. Biol. Chem. 276, 24068–24074 (2001).

  13. 13

    Joshi, A.A. & Struhl, K. Mol. Cell 20, 971–978 (2005).

  14. 14

    Reid, J.L., Moqtaderi, Z. & Struhl, K. Mol. Cell. Biol. 24, 757–764 (2004).

  15. 15

    Collins, S.R. et al. Nature 446, 806–810 (2007).

  16. 16

    Morris, S.A. et al. Eukaryot. Cell 4, 1446–1454 (2005).

  17. 17

    Li, X. & Manley, J.L. Genes Dev. 20, 1838–1847 (2006).

  18. 18

    Skowyra, D. et al. J. Biol. Chem. 276, 8734–8739 (2001).

  19. 19

    Sif, S., Saurin, A.J., Imbalzano, A.N. & Kingston, R.E. Genes Dev. 15, 603–618 (2001).

  20. 20

    Horn, P.J. & Peterson, C.L. Chromosome Res. 14, 83–94 (2006).

Download references

Acknowledgements

We thank C.J. Ingles and G. Cagney for critically reading the manuscript, M. Shales for help with artwork and R. Rothstein and D. Alvaro for sharing unpublished results.

Author information

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Roguev, A., Krogan, N. SIN-fully silent: HDAC complexes in fission yeast. Nat Struct Mol Biol 14, 358–359 (2007) doi:10.1038/nsmb0507-358

Download citation

Further reading