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A leak in the EAATs

Glutamate transporters in neuronal membranes are also known to catalyze a 'leak' of chloride ions, for unknown biological purposes. Now a glutamate transporter homolog from evolutionarily distant microorganisms has been shown to contain a similar chloride leak.

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Figure 1: Scheme of cotransport by an alternating-site mechanism.

Katie Ris

Figure 2: Relief of membrane polarization by Cl leak.

Katie Ris


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Miller, C. A leak in the EAATs. Nat Struct Mol Biol 14, 356–357 (2007).

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