Hitting transcription in all the right places

A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription. This activity is modulated by NADH binding, thereby supporting a link between cellular metabolism and gene expression.

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Figure 1: The transcriptional corepressor CtBP associates with a variety of repressive activities and is regulated by cellular NADH levels.

References

  1. 1

    Kim, J.H., Cho, E.J., Kim, S.T. & Youn, H.D. Nat. Struct. Mol. Biol. 12, 423–428 (2005).

    CAS  Article  Google Scholar 

  2. 2

    Boyd, J.M. et al. EMBO J. 12, 469–478 (1993).

    CAS  Article  Google Scholar 

  3. 3

    Schaeper, U. et al. Proc. Natl. Acad. Sci. USA 92, 10467–10471 (1995).

    CAS  Article  Google Scholar 

  4. 4

    Chinnadurai, G. Mol. Cell 9, 213–224 (2002).

    CAS  Article  Google Scholar 

  5. 5

    Nibu, Y., Zhang, H. & Levine, M. Science 280, 101–104 (1998).

    CAS  Article  Google Scholar 

  6. 6

    Nibu, Y. & Levine, M.S. Proc. Natl. Acad. Sci. USA 98, 6204–6208 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Poortinga, G., Watanabe, M. & Parkhurst, S.M. EMBO J. 17, 2067–2078 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Turner, J. & Crossley, M. Bioessays 23, 683–690 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Zhang, Q., Piston, D.W. & Goodman, R.H. Science 295, 1895–1897 (2002).

    CAS  PubMed  Google Scholar 

  10. 10

    Kumar, V. et al. Mol. Cell 10, 857–869 (2002).

    CAS  Article  Google Scholar 

  11. 11

    Shi, Y. et al. Nature 422, 735–738 (2003).

    CAS  Article  Google Scholar 

  12. 12

    Shi, Y. et al. Cell 119, 941–953 (2004).

    CAS  Article  Google Scholar 

  13. 13

    Moran, E. Curr. Opin. Genet. Dev. 3, 63–70 (1993).

    CAS  Article  Google Scholar 

  14. 14

    Arany, Z., Newsome, D., Oldread, E., Livingston, D.M. & Eckner, R. Nature 374, 81–84 (1995).

    CAS  Article  Google Scholar 

  15. 15

    Dhalluin, C. et al. Nature 399, 491–496 (1999).

    CAS  Article  Google Scholar 

  16. 16

    Jacobson, R.H., Ladurner, A.G., King, D.S. & Tjian, R. Science 288, 1422–1425 (2000).

    CAS  Article  Google Scholar 

  17. 17

    Manning, E.T., Ikehara, T., Ito, T., Kadonaga, J.T. & Kraus, W.L. Mol. Cell. Biol. 21, 3876–3887 (2001).

    CAS  Article  Google Scholar 

  18. 18

    Agalioti, T. et al. Cell 103, 667–678 (2000).

    CAS  Article  Google Scholar 

  19. 19

    Pieper, A.A., Verma, A., Zhang, J. & Snyder, S.H. Trends Pharmacol. Sci. 20, 171–181 (1999).

    CAS  Article  Google Scholar 

  20. 20

    Decker, P., Muller, S. Curr. Pharm. Biotechnol. 3, 275–283 (2002).

    CAS  Article  Google Scholar 

  21. 21

    Imai, S., Armstrong, C.M., Kaeberlein, M. & Guarente, L. Nature 403, 795–800 (2000).

    CAS  Article  Google Scholar 

  22. 22

    Landry, J. et al. Proc. Natl. Acad. Sci. USA 97, 5807–5811 (2000).

    CAS  Article  Google Scholar 

  23. 23

    Smith, J.S. et al. Proc. Natl. Acad. Sci. USA 97, 6658–6663 (2000).

    CAS  Article  Google Scholar 

  24. 24

    Tanner, K.G., Landry, J., Sternglanz, R. & Denu, J.M. Proc. Natl. Acad. Sci. USA 97, 14178–14182 (2000).

  25. 25

    Jackson, M.D. & Denu, J.M. J. Biol. Chem. 277, 18535–18544 (2002).

    CAS  Article  Google Scholar 

  26. 26

    Lin, S.J. & Guarente, L. Curr. Opin. Cell Biol. 15, 241–246 (2003).

    CAS  Article  Google Scholar 

  27. 27

    Guarente, L. & Picard, F. Cell 120, 473–482 (2005).

    CAS  Article  Google Scholar 

  28. 28

    Brunet, A. et al. Science 303, 2011–2015 (2004).

    CAS  Article  Google Scholar 

  29. 29

    Picard, F. et al. Nature 429, 771–776 (2004).

    CAS  Article  Google Scholar 

  30. 30

    Yang, Y., Hou, H., Haller, E.M., Nicosia, S.V. & Bai, W. EMBO J. 24, 1021–1032 (2005).

    CAS  Article  Google Scholar 

  31. 31

    Nemoto, S., Fergusson, M.M. & Finkel, T. Science 306, 2105–2108 (2004).

    CAS  Article  Google Scholar 

  32. 32

    Vaquero, A., Scher, M., Lee, D., Erdjument-Bromage, H., Tempst, P. Reinberg, D. Mol. Cell 16, 93–105 (2004).

    CAS  Article  Google Scholar 

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Acknowledgements

E.L. is supported by an E-STAR fellowship funded by the European Commission's FP6 Marie Curie Host fellowship for Early Stage Research Training and is a student in the European Molecular Biology Laboratory International PhD program.

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Lejeune, E., Ladurner, A. Hitting transcription in all the right places. Nat Struct Mol Biol 12, 390–392 (2005). https://doi.org/10.1038/nsmb0505-390

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