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Catching the common cold

The structure of a minor group human rhinovirus in complex with a receptor fragment reveals how the ligand-binding repeats of LDL receptor family proteins bind to these viruses and also suggests a preferred mode for partner recognition by these repeats.

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Figure 1: Structures of HRV–receptor complexes.
Figure 2: Virus-receptor and intramolecular LDL receptor interfaces.
Figure 3

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I am deeply indebted to D. Filman for back-calculation of the maps used to prepare Figure 1, and to both D. Filman and D. Bubeck for help with rendering the maps for the figure. I am also grateful to N. Verdaguer and colleagues for releasing their coordinates before publication. S.C.B. is supported by grants from the US National Institutes of Health (HL61001) and is a Pew Scholar in the Biomedical Sciences and an Established Investigator of the American Heart Association.

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Blacklow, S. Catching the common cold. Nat Struct Mol Biol 11, 388–390 (2004).

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