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miR-9 and TLX: chasing tails in neural stem cells

Development and maintenance of an organism require the precise spatiotemporal orchestration of stem cell proliferation and differentiation. In neurogenesis, a microRNA and an orphan nuclear receptor comprise a negative feedback loop that regulates neural stem cell fate.

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Figure 1: miR-9–TLX feedback loop in neural stem cells.

Katie Vicari

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Denli, A., Cao, X. & Gage, F. miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol 16, 346–347 (2009). https://doi.org/10.1038/nsmb0409-346

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