The functional assembly of a ciliate telomerase requires ordered RNA conformational changes mediated by a La motif–containing protein. This raises new questions about telomerase biogenesis and the evolutionary origin of the telomerase RNA.
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References
Blackburn, E.H., Greider, C.W. & Szostak, J.W. Nat. Med. 12, 1133–1138 (2006).
Schroeder, R., Barta, A. & Semrad, K. Nat. Rev. Mol. Cell Biol. 5, 908–919 (2004).
Collins, K. Nat. Rev. Mol. Cell Biol. 7, 484–494 (2006).
Stone, M.D. et al. Nature, advance online publication 25 February 2007 (doi:10.1038/nature05600).
Sperger, J.M. & Cech, T.R. Biochemistry 40, 7005–7016 (2001).
Lai, C.K., Miller, M.C. & Collins, K. Mol. Cell 11, 1673–1683 (2003).
Richards, R.J. et al. RNA 12, 1475–1485 (2006).
Mason, D.X., Goneska, E. & Greider, C.W. Mol. Cell. Biol. 23, 5606–5613 (2003).
Witkin, K.L. & Collins, K. Genes Dev. 18, 1107–1118 (2004).
Wolin, S.L. & Cedervall, T. Annu. Rev. Biochem. 71, 375–403 (2002).
Prathapam, R., Witkin, K.L. & O'Connor, C. Nat. Struct. Mol. Biol. 12, 252–257 (2005)
O'Connor, C.M. & Collins, K. Mol. Cell. Biol. 26, 2029–2036 (2006).
Zhuang, X. Annu. Rev. Biophys. Biomol. Struct. 34, 399–414 (2005).
Chapon, C., Cech, T.R. & Zaug, A.J. RNA 3, 1337–1351 (1997).
Seto, A.G., Zaug, A.J., Sobel, S.G., Wolin, S.L. & Cech, T.R. Nature 401, 177–180 (1999).
Chen, J.L. & Greider, C.W. Trends Biochem. Sci. 29, 183–192 (2004).
Jady, B.E., Bertrand, E. & Kiss, T. J. Cell Biol. 164, 647–652 (2004).
Nakamura, T.M. & Cech, T.R. Cell 92, 587–590 (1998).
Aigner, S. et al. EMBO J. 19, 6230–6239 (2000).
Chen, J.L. & Greider, C.W. Proc. Natl. Acad. Sci. USA 101, 14683–14684 (2004).
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Teixeira, M., Gilson, E. La sets the tone for telomerase assembly. Nat Struct Mol Biol 14, 261–262 (2007). https://doi.org/10.1038/nsmb0407-261
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DOI: https://doi.org/10.1038/nsmb0407-261
