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An accidental breach of a protein's natural defenses

Two recent studies provide a glimpse of the structure of an intermediate in the formation of β-2-microglobulin fibrils involved in dialysis-related amyloidosis.

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Figure 1: Schematic diagram of the origin of dialysis related amyloidosis.

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Dobson, C. An accidental breach of a protein's natural defenses. Nat Struct Mol Biol 13, 295–297 (2006). https://doi.org/10.1038/nsmb0406-295

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