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The second extracellular loop: a damper for G protein–coupled receptors?

Nature Structural & Molecular Biology volume 12, pages 287–288 (2005)Cite this article

A recent study suggests a novel role for the second extracellular loop of GPCRs: it may orchestrate a network of interactions that stabilize the inactive conformation of the receptor and control the on-off transition.

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Figure 1: The second extracellular loop (EC2) in GPCRs.

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Authors and Affiliations

  1. IGBMC, CNRS/INSERM/ULP, 1 rue Laurent Fries BP 10142, Illkirch, 67404, Cedex, France

    Dominique Massotte & Brigitte L Kieffer

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  1. Dominique Massotte
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  2. Brigitte L Kieffer
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Massotte, D., Kieffer, B. The second extracellular loop: a damper for G protein–coupled receptors?. Nat Struct Mol Biol 12, 287–288 (2005). https://doi.org/10.1038/nsmb0405-287

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