UNRaveling the regulation of dosage compensation

Translational inhibition of male-specific msl-2 messenger RNA by the female-specific protein SXL is crucial for X-chromosome dosage compensation in Drosophila melanogaster. Two recent studies identify an RNA-binding protein, UNR, as a novel corepressor that is recruited by SXL to the 3′ UTR of msl-2 mRNA for translation inhibition in females.

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Figure 1: Incorporation of the findings from Duncan et al.8 and Abaza et al.9 into the current model of translational repression of msl-2 mRNA by SXL.

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Shyu, A. UNRaveling the regulation of dosage compensation. Nat Struct Mol Biol 13, 189–190 (2006). https://doi.org/10.1038/nsmb0306-189

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