Two new crystal structures of ubiquitin (Ub) in complex with fragments of the endosomal proteins Rabex-5 and HRS show intriguing new modes of Ub binding and reveal that both fragments can bind two Ub molecules simultaneously.
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References
Hershko, A. Cell Death Differ. 12, 1191–1197 (2005).
Welchman, R.L., Gordon, C. & Mayer, R.J. Nat. Rev. Mol. Cell Biol. 6, 599–609 (2005).
Hicke, L. & Dunn, R. Annu. Rev. Cell Dev. Biol. 19, 141–172 (2003).
Urbe, S. Essays Biochem. 41, 81–98 (2005).
Katzmann, D.J., Odorizzi, G. & Emr, S.D. Nat. Rev. Mol. Cell Biol. 3, 893–905 (2002).
Hirano, S. et al. Nat. Struct. Mol. Biol. 13, 272–277 (2006).
Lee, S. et al. Nat. Struct. Mol. Biol. 13, 264–271 (2006).
Pickart, C.M. & Fushman, D. Curr. Opin. Chem. Biol. 8, 610–616 (2004).
Hicke, L., Schubert, H.L. & Hill, C.P. Nat. Rev. Mol. Cell Biol. 6, 610–621 (2005).
VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M. & Wolberger, C. Cell 105, 711–720 (2001).
Sundquist, W.I. et al. Mol. Cell 13, 783–789 (2004).
Hamilton, K.S. et al. Structure 9, 897–904 (2001).
Teo, H., Veprintsev, D.B. & Williams, R.L. J. Biol. Chem. 279, 28689–28696 (2004).
Kang, R.S. et al. Cell 113, 621–630 (2003).
Prag, G. et al. Cell 113, 609–620 (2003).
Raiborg, C. & Stenmark, H. Cell Struct. Funct. 27, 403–408 (2002).
Mattera, R., Tsai, Y.C., Weissman, A.M. & Bonifacino, J.S. J Biol. Chem., published online 5 January 2006 (10.1074/jbc.M509939200).
Young, P., Deveraux, Q., Beal, R.E., Pickart, C.M. & Rechsteiner, M. J. Biol. Chem. 273, 5461–5467 (1998).
Hofmann, K. & Falquet, L. Trends Biochem. Sci. 26, 347–350 (2001).
Mueller, T.D. & Feigon, J. EMBO J. 22, 4634–4645 (2003).
Swanson, K.A., Kang, R.S., Stamenova, S.D., Hicke, L. & Radhakrishnan, I. EMBO J. 22, 4597–4606 (2003).
Wertz, I.E. et al. Nature 430, 694–699 (2004).
Sloper-Mould, K.E., Jemc, J.C., Pickart, C.M. & Hicke, L. J. Biol. Chem. 276, 30483–30489 (2001).
Prag, G. et al. Proc. Natl Acad. Sci. USA 102, 2334–2339 (2005).
Akutsu, M. et al. FEBS Lett. 579, 5385–5391 (2005).
Kawasaki, M. et al. Genes Cells 10, 639–654 (2005).
Slagsvold, T. et al. J. Biol. Chem. 280, 19600–19606 (2005).
Lim, W.A. Curr. Opin. Struct. Biol. 12, 61–68 (2002).
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Alam, S., Sundquist, W. U2. Nat Struct Mol Biol 13, 186–188 (2006). https://doi.org/10.1038/nsmb0306-186
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DOI: https://doi.org/10.1038/nsmb0306-186