The first structure of a ribozyme that catalyzes the stereospecific carbon-carbon bond formation between two small molecules shows how an RNA active site can perform the synthetically important Diels-Alder reaction. Surprisingly, the ribozyme active site shares structural features with proteins that catalyze the same reaction.
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Acknowledgements
J.N.P. is supported by the US National Aeronautics and Space Administration Office of Space Science Graduate Student Research Program. A.R.F. is a W.M. Keck Foundation distinguished young scholar in medical research.
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Pitt, J., Ferré-D'Amaré, A. How RNA closes a Diel. Nat Struct Mol Biol 12, 206–208 (2005). https://doi.org/10.1038/nsmb0305-206
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DOI: https://doi.org/10.1038/nsmb0305-206
