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Tudor hooks up with DNA repair

Nature Structural & Molecular Biology volume 14, pages 98–99 (2007)Cite this article

Histone lysine methylation has a central role in transcriptional regulation and has recently been linked to DNA damage repair. Now it has been shown that the DNA damage repair factor 53BP1 is recruited to DNA double-strand breaks by its tandem tudor domain, which specifically recognizes histone H4 dimethylated at lysine 20.

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Figure 1: Methyllysine recognition by tudor domains, chromodomains and PHD fingers.

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Authors and Affiliations

  1. Lorenzo Corsini and Michael Sattler are at the European Molecular Biology Laboratory, Meyerhofstr. 1, D-69117 Heidelberg, Germany,

    Lorenzo Corsini & Michael Sattler

  2. Michael Sattler is at the GSF-Research Center for Environment and Health, Ingolstädter, Landstr. 1, 85764, Neuherberg, Gemany and Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany. sattler@embl.de,

    Michael Sattler

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  1. Lorenzo Corsini
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Corsini, L., Sattler, M. Tudor hooks up with DNA repair. Nat Struct Mol Biol 14, 98–99 (2007). https://doi.org/10.1038/nsmb0207-98

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