Tudor hooks up with DNA repair

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Histone lysine methylation has a central role in transcriptional regulation and has recently been linked to DNA damage repair. Now it has been shown that the DNA damage repair factor 53BP1 is recruited to DNA double-strand breaks by its tandem tudor domain, which specifically recognizes histone H4 dimethylated at lysine 20.

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Figure 1: Methyllysine recognition by tudor domains, chromodomains and PHD fingers.

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Corsini, L., Sattler, M. Tudor hooks up with DNA repair. Nat Struct Mol Biol 14, 98–99 (2007) doi:10.1038/nsmb0207-98

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