Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?

Nature Structural & Molecular Biology volume 14, pages95–97(2007)Cite this article

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A timely study in this issue reports the high-resolution crystal structure of the human plasma protein cholesteryl ester transfer protein (CETP) with its natural lipid ligands. The crystal structure will enhance both basic research on CETP-mediated cholesterol lipid transfer and the design of new drugs that increase plasma high density lipoprotein (HDL) cholesterol.

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Figure 1: Hypothetical scheme of CETP transfer of cholesteryl ester (CE) and triglyceride (TG) between HDL and triglyceride-rich lipoproteins.

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Affiliations

  1. James A. Hamilton is in the Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany St., Boston, Massachusetts 02118-2526, USA

    • James A Hamilton

  2. Richard J. Deckelbaum is in the Institute of Human Nutrition, Columbia University Medical Center, 630 W. 168th St., New York, New York 10032, USA. jhamilt@bu.edu

    • Richard J Deckelbaum

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Hamilton, J., Deckelbaum, R. Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?. Nat Struct Mol Biol 14, 95–97 (2007) doi:10.1038/nsmb0207-95

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