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Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?

A timely study in this issue reports the high-resolution crystal structure of the human plasma protein cholesteryl ester transfer protein (CETP) with its natural lipid ligands. The crystal structure will enhance both basic research on CETP-mediated cholesterol lipid transfer and the design of new drugs that increase plasma high density lipoprotein (HDL) cholesterol.

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Figure 1: Hypothetical scheme of CETP transfer of cholesteryl ester (CE) and triglyceride (TG) between HDL and triglyceride-rich lipoproteins.


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Hamilton, J., Deckelbaum, R. Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?. Nat Struct Mol Biol 14, 95–97 (2007).

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