A recent study shows that the Drosophila melanogaster proapoptotic protein Reaper inhibits protein synthesis by direct binding to 40S ribosomal subunits, which affects recognition of initiation codons and ribosomal subunit joining.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pestova, T.V. et al. Proc. Natl. Acad. Sci. USA 98, 7029–7036 (2001).
Morley, S.J., Coldwell, M.J. & Clemens, M.J. Cell Death Differ. 12, 571–584 (2005).
Peterson, C., Carney, G.E., Taylor, B.J. & White, K. Development 129, 1467–1476 (2002).
Lohmann, I., McGinnis, N., Bodmer, M. & McGinnis, W. Cell 110, 457–466 (2002).
Goyal, L., McCall, K., Agapite, J., Hartwieg, E. & Steller, H. EMBO J. 19, 589–597 (2000).
McCarthy, J.V. & Dixit, V.M. J. Biol. Chem. 273, 24009–24015 (1998).
Tait, S.W., Werner, A.B., de Vries, E. & Borst, J. Cell Death Differ. 11, 800–811 (2004).
Holley, C.L., Olson, M.R., Colon-Ramos, D.A. & Kornbluth, S. Nat. Cell Biol. 4, 439–444 (2002).
Colón-Ramos, D.A. et al. Nat. Struct. Mol. Biol. 13, 103–111 (2006).
Unbehaun, A., Borukhov, S.I., Hellen, C.U. & Pestova, T.V. Genes Dev. 18, 3078–3093 (2003).
Algire, M.A., Maag, D. & Lorsch, J.A. Mol. Cell 20, 251–262 (2005).
Pestova, T.V. & Hellen, C.U. Genes Dev. 17, 181–186 (2003).
Kaminski, A., Howell, R.T. & Jackson, R.J. EMBO J. 9, 3753–3759 (1990).
Wilson, J.E., Pestova, T.V., Hellen, C.U. & Sarnow, P. Cell 102, 511–520 (2000).
Odon, O.W., Kramer, G., Henderson, A.B., Pinphanichakaran, P. & Hardesty, B. J. Biol. Chem. 253, 1808–1816 (1978).
Hettinger, T.P. & Craig, L.C. Biochemistry 9, 1224–1232 (1970).
Pioletti, M. et al. EMBO J. 20, 1829–1839 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pestova, T., Hellen, C. Translation, interrupted. Nat Struct Mol Biol 13, 98–99 (2006). https://doi.org/10.1038/nsmb0206-98
Issue Date:
DOI: https://doi.org/10.1038/nsmb0206-98