A recent study shows that the Mediator complex is not universally recruited to the promoters of actively transcribed genes in yeast, suggesting that the requirement for Mediator in transcription activation is an activator-dependent property.
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Lewis, B., Reinberg, D. Promoter activation when the ChIPs are down. Nat Struct Mol Biol 13, 96–97 (2006). https://doi.org/10.1038/nsmb0206-96
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DOI: https://doi.org/10.1038/nsmb0206-96