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RNA stability: is it the endo' the world as we know it?

Nature Structural & Molecular Biology volume 16, pages 9–10 (2009)Cite this article

Endonucleases have generally not been considered among the major factors in well-studied mRNA-decay and quality-control pathways in mammals and yeast. However, two important players in these pathways, the exosome and SMG6, have now been shown to contain functionally significant endonucleolytic activities.

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Figure 1: PIN 1 domain structure.
Figure 2: Possible pathways of nuclease digestion of RNA substrates by the exosome.

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  1. Jeffrey Wilusz is in the Department of Microbiology Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, USA. jeffrey.wilusz@colostate.edu,

    Jeffrey Wilusz

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Wilusz, J. RNA stability: is it the endo' the world as we know it?. Nat Struct Mol Biol 16, 9–10 (2009). https://doi.org/10.1038/nsmb0109-9

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