Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

The Hsp90 mosaic: a picture emerges

Hsp90s, molecular chaperones critically involved in many essential cellular processes, were the focus of a recent international conference held in Seeon, Germany. The scope of the conference ranged from structural and mechanistic insights all the way to medical applications.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The ATPase cycle of Hsp90 proteins.
Figure 2: A cycle of phosphorylation and dephosphorylation of Cdc37 is necessary for kinase-client loading onto Hsp90.

References

  1. Pratt, W.B. & Toft, D.O. Exp. Biol. Med. (Maywood) 228, 111–133 (2003).

    Article  CAS  Google Scholar 

  2. Shiau, A.K., Harris, S.F., Southworth, D.R. & Agard, D.A. Cell 127, 329–340 (2006).

    Article  CAS  Google Scholar 

  3. Southworth, D.R. & Agard, D.A. Mol. Cell 32, 631–640 (2008).

    Article  CAS  Google Scholar 

  4. Leskovar, A., Wegele, H., Werbeck, N.D., Buchner, J. & Reinstein, J. J. Biol. Chem. 283, 11677–11688 (2008).

    Article  CAS  Google Scholar 

  5. Siligardi, G. et al. J. Biol. Chem. 279, 51989–51998 (2004).

    Article  CAS  Google Scholar 

  6. Scroggins, B.T. et al. Mol. Cell 25, 151–159 (2007).

    Article  CAS  Google Scholar 

  7. Martinez-Ruiz, A. et al. Proc. Natl. Acad. Sci. USA 102, 8525–8530 (2005).

    Article  CAS  Google Scholar 

  8. Johnson, J.L. & Brown, C. Cell Stress Chaperones 14, 83–94 (2008).

    Article  Google Scholar 

  9. Vaughan, C.K. et al. Mol. Cell 31, 886–895 (2008).

    Article  CAS  Google Scholar 

  10. Kadota, Y. et al. EMBO Rep. 9, 1209–1215 (2008).

    Article  CAS  Google Scholar 

  11. Zhang, M. et al. EMBO J. 27, 2789–2798 (2008).

    Article  CAS  Google Scholar 

  12. Zhao, R. et al. J. Cell Biol. 180, 563–578 (2008).

    Article  CAS  Google Scholar 

  13. McClellan, A.J. et al. Cell 131, 121–135 (2007).

    Article  CAS  Google Scholar 

  14. Hawkins, T.A. et al. Development 135, 1147–1156 (2008).

    Article  CAS  Google Scholar 

  15. Etard, C., Roostalu, U. & Strahle, U. J. Cell Biol. 180, 1163–1175 (2008).

    Article  CAS  Google Scholar 

  16. Cheng, C.F. et al. Mol. Cell. Biol. 28, 3344–3358 (2008).

    Article  CAS  Google Scholar 

  17. Li, W. et al. EMBO J. 26, 1221–1233 (2007).

    Article  CAS  Google Scholar 

  18. Wanderling, S. et al. Mol. Biol. Cell 18, 3764–3775 (2007).

    Article  CAS  Google Scholar 

  19. Barluenga, S. et al. Angew. Chem. Int. Edn Engl. 47, 4432–4435 (2008).

    Article  CAS  Google Scholar 

  20. Frey, S., Leskovar, A., Reinstein, J. & Buchner, J. J. Biol. Chem. 282, 35612–35620 (2007).

    Article  CAS  Google Scholar 

  21. Vaughan, C.K., Piper, P.W., Pearl, L.H. & Prodromou, C. FEBS J. published online, doi:10.1111/j.1742-4658.2008.06773.x (20 November 2008).

  22. Vaughan, C.K. et al. Mol. Cell 23, 697–707 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mayer, M., Prodromou, C. & Frydman, J. The Hsp90 mosaic: a picture emerges. Nat Struct Mol Biol 16, 2–6 (2009). https://doi.org/10.1038/nsmb0109-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0109-2

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing