DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.
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References
Huen, M.S. et al. Cell 131, 901–914 (2007).
Kolas, N.K. et al. Science 318, 1637–1640 (2007).
Mailand, N. et al. Cell 131, 887–900 (2007).
Wang, B. & Elledge, S.J. Proc. Natl. Acad. Sci. USA, published online 5 December 2007 (doi:10.1073/pnas.0710061104).
Matsuoka, S. et al. Science 316, 1160–1166 (2007).
Stucki, M. & Jackson, S.P. DNA Repair (Amst.) 5, 534–543 (2006).
Morris, J.R. & Solomon, E. Hum. Mol. Genet. 13, 807–817 (2004).
Polanowska, J., Martin, J.S., Garcia-Muse, T., Petalcorin, M.I. & Boulton, S.J. EMBO J. 25, 2178–2188 (2006).
Ruffner, H., Joazeiro, C.A., Hemmati, D., Hunter, T. & Verma, I.M. Proc. Natl. Acad. Sci. USA 98, 5134–5139 (2001).
Zhao, G.Y. et al. Mol. Cell 25, 663–675 (2007).
Sobhian, B. et al. Science 316, 1198–1202 (2007).
Liu, Z., Wu, J. & Yu, X. Nat. Struct. Mol. Biol. 14, 716–720 (2007).
Kim, H., Chen, J. & Yu, X. Science 316, 1202–1205 (2007).
Wang, B. et al. Science 316, 1194–1198 (2007).
Bekker-Jensen, S. et al. J. Cell Biol. 173, 195–206 (2006).
Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. & Lukas, J. J. Cell Biol. 170, 201–211 (2005).
Durocher, D. et al. Mol. Cell 6, 1169–1182 (2000).
Plans, V. et al. J. Cell. Biochem. 97, 572–582 (2006).
Bergink, S. et al. Genes Dev. 20, 1343–1352 (2006).
Pickart, C.M. & Fushman, D. Curr. Opin. Chem. Biol. 8, 610–616 (2004).
Bothos, J., Summers, M.K., Venere, M., Scolnick, D.M. & Halazonetis, T.D. Oncogene 22, 7101–7107 (2003).
Ito, K. et al. Eur. J. Biochem. 268, 2725–2732 (2001).
Nicassio, F. et al. Curr. Biol. 17, 1972–1977 (2007).
Chen, X., Arciero, C.A., Wang, C., Broccoli, D. & Godwin, A.K. Cancer Res. 66, 5039–5046 (2006).
Dong, Y. et al. Mol. Cell 12, 1087–1099 (2003).
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Bennett, E., Harper, J. DNA damage: ubiquitin marks the spot. Nat Struct Mol Biol 15, 20–22 (2008). https://doi.org/10.1038/nsmb0108-20
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DOI: https://doi.org/10.1038/nsmb0108-20
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